RapamycinFungusV1, Main, Exploration, bibRecord, 001622

Influence of genotype and nutrition on survival and metabolism of starving yeast.

Identifieur interne : 001622 ( Main/Exploration ); précédent : 001621; suivant : 001623

Influence of genotype and nutrition on survival and metabolism of starving yeast.

Auteurs : Viktor M. Boer [États-Unis] ; Sasan Amini ; David Botstein

Source :

Proceedings of the National Academy of Sciences of the United States of America [ 1091-6490 ] ; 2008.

RBID : pubmed:18456835

Descripteurs français

KwdFr :
- Aliments (MeSH), Chromosomes de champignon (MeSH), Glucose (métabolisme), Génotype (MeSH), Leucine (déficit), Milieux de culture (MeSH), Mutation (génétique), Numération de colonies microbiennes (MeSH), Phosphates (déficit), Phénomènes physiologiques nutritionnels (MeSH), Réseaux de régulation génique (MeSH), Saccharomyces cerevisiae (croissance et développement), Saccharomyces cerevisiae (génétique), Saccharomyces cerevisiae (isolement et purification), Saccharomyces cerevisiae (métabolisme), Uracile (métabolisme), Viabilité microbienne (MeSH).
MESH :
- croissance et développement : Saccharomyces cerevisiae.
- déficit : Leucine, Phosphates.
- génétique : Mutation, Saccharomyces cerevisiae.
- isolement et purification : Saccharomyces cerevisiae.
- métabolisme : Glucose, Saccharomyces cerevisiae, Uracile.
- Aliments, Chromosomes de champignon, Génotype, Milieux de culture, Numération de colonies microbiennes, Phénomènes physiologiques nutritionnels, Réseaux de régulation génique, Viabilité microbienne.

English descriptors

KwdEn :
- Chromosomes, Fungal (MeSH), Colony Count, Microbial (MeSH), Culture Media (MeSH), Food (MeSH), Gene Regulatory Networks (MeSH), Genotype (MeSH), Glucose (metabolism), Leucine (deficiency), Microbial Viability (MeSH), Mutation (genetics), Nutritional Physiological Phenomena (MeSH), Phosphates (deficiency), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae (growth & development), Saccharomyces cerevisiae (isolation & purification), Saccharomyces cerevisiae (metabolism), Uracil (metabolism).
MESH :
- chemical , deficiency : Leucine, Phosphates.
- chemical , metabolism : Glucose, Uracil.
- chemical : Culture Media.
- genetics : Mutation, Saccharomyces cerevisiae.
- growth & development : Saccharomyces cerevisiae.
- isolation & purification : Saccharomyces cerevisiae.
- metabolism : Saccharomyces cerevisiae.
- Chromosomes, Fungal, Colony Count, Microbial, Food, Gene Regulatory Networks, Genotype, Microbial Viability, Nutritional Physiological Phenomena.

Abstract

Starvation of yeast cultures limited by auxotrophic requirements results in glucose wasting and failure to achieve prompt cell-cycle arrest when compared with starvation for basic natural nutrients like phosphate or sulfate. We measured the survival of yeast auxotrophs upon starvation for different nutrients and found substantial differences: When deprived of leucine or uracil, viability declined exponentially with a half-life of <2 days, whereas when the same strains were deprived of phosphate or sulfate, the half-life was approximately 10 days. The survival rates of nongrowing auxotrophs deprived of uracil or leucine depended on the carbon source available during starvation, but were independent of the carbon source during prior growth. We performed an enrichment procedure for mutants that suppress lethality during auxotrophy starvation. We repeatedly found loss-of-function mutations in a number of functionally related genes. Mutations in PPM1, which methylates protein phosphatase 2A, and target of rapamycin (TOR1) were characterized further. Deletion of PPM1 almost completely suppressed the rapid lethality and substantially suppressed glucose wasting during starvation for leucine or uracil. Suppression by a deletion of TOR1 was less complete. We suggest that, similar to the Warburg effect observed in tumor cells, starving yeast auxotrophs wastes glucose as a consequence of the failure of conserved growth control pathways. Furthermore, we suggest that our results on condition-dependent chronological lifespan have important implications for the interpretation and design of studies on chronological aging.

DOI: 10.1073/pnas.0802601105
PubMed: 18456835
PubMed Central: PMC2383937

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Starvation of yeast cultures limited by auxotrophic requirements results in glucose wasting and failure to achieve prompt cell-cycle arrest when compared with starvation for basic natural nutrients like phosphate or sulfate. We measured the survival of yeast auxotrophs upon starvation for different nutrients and found substantial differences: When deprived of leucine or uracil, viability declined exponentially with a half-life of <2 days, whereas when the same strains were deprived of phosphate or sulfate, the half-life was approximately 10 days. The survival rates of nongrowing auxotrophs deprived of uracil or leucine depended on the carbon source available during starvation, but were independent of the carbon source during prior growth. We performed an enrichment procedure for mutants that suppress lethality during auxotrophy starvation. We repeatedly found loss-of-function mutations in a number of functionally related genes. Mutations in PPM1, which methylates protein phosphatase 2A, and target of rapamycin (TOR1) were characterized further. Deletion of PPM1 almost completely suppressed the rapid lethality and substantially suppressed glucose wasting during starvation for leucine or uracil. Suppression by a deletion of TOR1 was less complete. We suggest that, similar to the Warburg effect observed in tumor cells, starving yeast auxotrophs wastes glucose as a consequence of the failure of conserved growth control pathways. Furthermore, we suggest that our results on condition-dependent chronological lifespan have important implications for the interpretation and design of studies on chronological aging.</div>
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	Serveur d'exploration sur la rapamycine et les champignons
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Influence of genotype and nutrition on survival and metabolism of starving yeast.

Influence of genotype and nutrition on survival and metabolism of starving yeast.

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